A ANTI-INFLAMMATORY EFFECT OF MATOA LEAF ETHANOL EXTRACT (Pometia pinnata J.R Forst & G. Forst) IN MALE RATS (Rattus norvegicus)
Abstract
Inflammation is the body's normal response to injury or tissue damage which is characterized by heat (calor), pain (dolor), swelling (tumor) and redness (rubor). Matoa leaves contain flavonoid compounds which have anti-inflammatory properties. The purpose of this study was to determine the effect anti-inflammatory of the ethanol extract of matoa leaves (Pometia Pinnata J.R Forst & G. Forst) in male rats (Rattus norvegicus). This study used 25 rat test animals which were divided into 5 treatment groups, group I negative control in the form of 1% Na CMC suspension, group II positive control in the form of diclofenac sodium suspension, groups III, IV and V were given a suspension of ethanol extract of matoa leaves with concentrations of 200 mg/kgBB, 400 mg/kgBB and 800 mg/kgBB. Measurements were made every 1 hour after administration of a comparison or test extract for 6 hours and then recorded. The results showed that the ethanol extract of matoa leaves had the potential as an anti-inflammatory candidate with the most effective dose in reducing the volume and diameter of edema was a dose of 400 mg/kgBB.
References
[1] Maulana et al., 2020. Uji Efektifitas Ekstrak Kulit Petai (Parkia speciosa Hassk) Terhadap Mencit (Mus musculus) Sebagai Anti Inflamasi. Jurnal Ilmu Kefarmasian. 1(2) : 80-84.
[2] Ricciotti E & FitzGerald G.A. 2011. Prostaglandins and Inflammation. Arterioscler Thromb Vasc Biol. 31(5) : 986-1000.
[3] Sudirman et al., 2017. Aktivitas Antiinflamasi Ekstrak Etanol Daun Beluntas (Pluchea indica L.). Galenika Journal of Pharmacy. 3(2) : 191- 198.
[4] Firestein, G.S, 2009. Etiology and pathogenesis of rheumatoid arthritis. In: Firestein GS, Budd RC, Harris Jr ED, McInnes IB, Ruddy S, Sergent JS, editors. Kelley’s textbook of rheumatology. Saunders Elsevier Inc. Philadelphia.
[5] Al-Saadany et al., 2015. Th17 Cells And Serum IL-17 In Rheumatoid Arthritis Patients: Correlation With Disease Activity And Severity. The Egyptian Rheumatologist: Elsevier. 38(1) : 1-7.
[6] Riskesdas. 2018. Hasil Utama Riset Kesehata Dasar Tahun 2018. Badan Penelitian dan Pengembangan Kesehatan Kementrian RI. 53(9) : 1689-1899
[7] Andri et al., 2020. Tingkat Pengetahuan Terhadap Penanganan Penyakit Rheumatoid Arthritis Pada Lansia. Jurnal Kesmas Asclepius. 2(1) : 12-21.
[8] Katzung et al., 2014. Farmakologi Dasar & Klinik, Ed. 12 vol. 2. Penerbit Buku Kedokteran EGC. Jakarta.
[9] Gomez-Acebo et al., 2018. Epidemiology of non-steroidal antiinflammatory drugs consumption in Spain. The MCC-Spain study. BMC Public Health. 18(1) : 1-13.
[10]Wongrakpanich et al., 2018. A Comprehensive Review of NonSteroidal AntiInflammatory Drug Use in The Elderly. Aging and Disease. 9(1) : 143-150.
[11] Fitriyanti et al., 2020. Efek Antiinflamasi Infusa Bunga Asoka (Ixora coccinea l) pada Tikus Jantan yang Diinduksi Karagenan. JKS. 2(4) : 335-359.
[12] Lely, N. 2016. Efektifitas beberapa fraksi daun matoa (Pometia pinnata JR Forst. & G. Forst.) sebagai antimikroba. Jurnal Ilmiah Bakti Farmasi. 1(1) : 51-59.
[13] Hamzah et al., 2021. Potensi Ekstrak Buah Matoa (Pometia Pinnata) Sebagai Sumber Antioksidan: Literatur Review. JFSP. 7(1) : 59-66.
[14] Martiningsih et al., 2016. Skrining Fitokimia Dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Matoa (Pometia pinnata) dengan Metode DPPH. Journal of Ocular Pharmacology and Therapeutics. 3(3) : 332-338.
[15] Parlin et al., 2022. Skrining Fitokimia Dan Uji Sitotoksisitas Ekstrak Etanol Daun Matoa (Pometia Pinnata) Dengan Metode Bslt. Farmasainkes. 2(1):38-48.
[16] Salimi et al., 2021. Sintesis dan Karakterisasi Carboxymethyl Cellulose Sodium (Na-CMC) dari Selulosa Eceng Gondok (Eichhornia crassipes) dengan Media Reaksi EtanolIsobutanol. Jambura Journal of Chemistry. 3(1) : 1-11.
[17] Astika et al., 2021. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Kayu Manis (Cinnamomum burmanni) Pada Mencit Putih Jantan. Jurnal Ilmiah Manuntung. 8(1) : 14- 23.
[18] Wahyuni, S. 2016. Uji Aktivitas Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Terhadap Mencit (Mus musculus) Sebagai Antiinflamasi. Skripsi. Universitas Islam Negeri Alauddin, Makassar.
[19] Hardman, J.G. 2001. The Pharmacological Basis of Therapeutics 10 th ed. McGraw-Hill Pub. New York.
[20] Agustin, R & Ratih, H. 2015. Profil Disolusi Tablet Sustained Release Natrium Diklofenak dengan Menggunakan Matriks Metolose 90 SH 4000. Jurnal Sains Farmasi & Klinik. 1(2) : 176-183.
[21] Riansyah et al., 2015. Uji aktivitas antiinflamasi ekstrak daun ubi jalar ungu (Ipomoea Batatas (L.) Lamk) terhadap tikus wistar jantan. Prosiding Penelitian SPeSIA. 1(2) : 630-636.
[22] Khotimah SN & Muhtadi A. 2015. Review Artikel: Beberapa Tumbuhan Yang Mengandung Senyawa Aktif Antiinflamasi. Farmaka Suplemen. 14(2) : 28–40.
